Professor of Occupational and Environmental Health
Department of Occupational and Environmental Health
* wangaiguo@mails.tjmu.edu.cn
Overview
Professor of the second grade
Doctoral supervisor
Scholar of Central China (Distinguished duty)
Principal for national quality resources sharing course Environmental Health
Academic Areas
Environmental Toxicology
Research Interests
Toxicological studies to investigate the neurotoxicity of exogenous compounds and the underlying molecular mechanisms
Selected Professional Affiliations
Commissioner, Endemiology Council, Chinese Medical Society
Vice Chair, Endemiology Council, Preventive Medicine Association of Hubei
Council Member, Toxicology Society of Hubei
Commissioner, Health Toxicology Council, Chinese Preventive Medicine Association
Commissioner, Neurotoxicology Council, Chinese Toxicology Society
Editorial Board Member, Chinese Journal of endemiology
Courses Taught
Environmental Health / Preventive Medicine
Awards and Honors
2013 Natural Science Award, Award of Science and Technology, Hubei
2011 Natural Science Award, Award for Outstanding Achievements in Scientific Research of Institutions of Higher Learning, Ministry of Education
2006-2008 New Century Excellent Talents Award, Ministry of Education
Education
1997-1999 Ph.D., University of Ulm, Ulm, Germany, Specialization: Molecular Biology
1989-1991 M.S., Tongji Medical University, Wuhan, China, Major: Environmental Health
1982-1987 B.S., Hunan Medical University, Hunan, China, Major: Medicine and Public Health
Professional/working Experience
2004-present Professor, Department of Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
2001-2004 Associate Professor, Department of Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
1993-2001 Lecturer, Department of Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
1997-1999 Research fellow, University of Ulm, Ulm, Germany
1987-1993 Assistant professor, Department of Environmental Health, School of Public Health, Tongji Medical University, Wuhan, Hubei, China
Past and ongoing projects, funding, programs
2018-2021 Roles and mechanisms of TFEB-mediated lysosomal dysfunction in PBDE-47 developmental neurotoxicity, NSFC, PI (No. 81773388)
2015-2019 Effects of mitochondrial dynamics alterations on fluorine neurotoxicity and resveratrol intervention research, Key projects of NSFC, PI (No. 81430076)
2015 Application of digital PET in the study of neurotoxicity of environmental pollutants, Independent innovation fund for key innovation teams, Huazhong University of Science and Technology
2013-2016 Roles of autophagy and apoptosis in PBDE-47 neurotoxicity, NSFC, PI (No. 81273021)
2011-2013 Roles of endoplasmic reticulum stress and UPR signaling pathway in PBDE-47 neurotoxicity, NSFC, PI (No. 81072266)
2009-2011 Role of cell membrane death receptor signaling pathway in PBDE-47 neurotoxicity, NSFC, PI (No. 30872081)
2007-2009 Roles of Fas receptor and Caspases signaling pathway in fluorine neurotoxicity, NSFC, PI (No. 30671819)
Select Publications
Journal Article
# Co-first author
*Corresponding author
1. Guoyu Zhou#, Lu Yang#, Chen Luo, Hongliang Liu, Pei Li, Yushan Cui, Li Liu, Xingchen Yu, Qiang Zeng, Jingwen Chen, Qian Zhao, Lixin Dong, Qiang Niu, Shun Zhang*, Aiguo Wang*. Low-to-moderate fluoride exposure, relative mitochondrial DNA levels, and dental fluorosis in Chinese children. Environ Int. 2019, 127：70-77. DOI:10.1016/j.envint.2019.03.033
2. Qian Zhao, Qiang Niu, Jingwen Chen, Tao Xia, Guoyu Zhou, Pei Li, Lixin Dong, Chunyan Xu, Zhiyuan Tian, Chen Luo, Luming Liu, Shun Zhang*, Aiguo Wang*. Roles of mitochondrial fission inhibition in developmental fluoride neurotoxicity:mechanisms of action in vitro and associations with cognition in rats and children. Arch Toxicol. 2019, 93:709-726. DOI: 10.1007/s00204-019-02390-0
3. Pei Li, Luming Liu, Guoyu Zhou, Zhiyuan Tian, Chen Luo, Tao Xia, Jingwen Chen, Qiang Niu, Lixin Dong, Qian Zhao, Aiguo Wang*, Shun Zhang*. Perigestational exposure to low doses of PBDE-47 induces excessive ER stress, defective autophagy and the resultant apoptosis contributing to maternal thyroid toxicity. Sci Total Environ. 2018, 645(15): 363-371. DOI: 10.1016/j.scitotenv.2018.07.138
4. Jingwen Chen, Qiang Niu, Tao Xia, Guoyu Zhou, Pei Li, Qian Zhao, Chunyan Xu, Lixin Dong, Shun Zhang*, Aiguo Wang*. ERK1/2-mediated disruption of BDNF–TrkB signaling causes synaptic impairment contributing to fluoride–induced developmental neurotoxicity. Toxicology. 2018, 410: 222-230. DOI: 10.1016/j.tox.2018.08.009
5. Xingchen Yu, Jingwen Chen, Yonggang Li, Hongliang Liu, Changchun Hou, Qiang Zeng, Yushan Cui, Liang Zhao, Pei Li, Ziquan Zhou, Shuo Pang, Sha Tang, Kunming Tian, Qian Zhao, Lixin Dong, Chunyan Xu, Xiao Zhang, Shun Zhang*, Li Liua**, Aiguo Wang*. Threshold effects of moderately excessive fluoride exposure on children's health: A potential association between dental fluorosis and loss of excellent intelligence. Environ Int. 2018, 118:116-124. DOI: 10.1016/j.envint.2018.05.042
6. Qiang Niu, Jingwen Chen, Tao Xia, Pei Li, Guoyu Zhou, Chunyan Xu, Qian Zhao, Lixin Dong, Shun Zhang*, Aiguo Wang**. Excessive ER stress and the resulting autophagic flux dysfunction contribute to fluoride-induced neurotoxicity. Environ Pollut. 2018, 233: 889-899. DOI: 10.1016/j.envpol.2017.09.015
7. Shun Zhang, Yihu Chen, Xue Wu, Hui Gao, Rulin Ma, Chunyang Jiang, Gang kuang, Guodong Zhao, Tao Xia, Xiaofei Zhang, Rongrong Lei, Cheng Zhang, Pei Li, Chunyan Xu, Aiguo Wang*. The Pivotal Role of Ca2+ Homeostasis in PBDE-47-Induced Neuronal Apoptosis. Mol Neurobiol. 2016, 53:7078-7088. DOI: 10.1007/s12035-015-9573-8
8. Shun Zhang, Qiang Niu, Hui Gao, Rulin Ma, Rongrong Lei, Cheng Zhang, Tao Xia, Pei Li, Chunyan Xu, Chao Wang, Jingwen Chen, Lixing Dong, Qian Zhao, Aiguo Wang*. Excessive apoptosis and defective autophagy contribute to developmental testicular toxicity induced by fluoride. Environ Pollut. 2016, 212:97-104. DOI: 10.1016/j.envpol.2016.01.059
9. Shun Zhang#, Xiaofei Zhang#, Hongliang Liu, Weidong , Zhizhong Guan, Qiang Zeng, Chunyang Jiang, Hui Gao, Cheng Zhang, Rongrong Lei, Tao Xia, Zhenglun Wang, Lu Yang, Yihu Chen, Xue Wu, Yushan Cui, Linyu Yu, and Aiguo Wang*. Modifying effect of COMT gene polymorphism and a predictive role for proteomics analysis in children’s intelligence in endemic fluorosis area in Tianjin, China. Toxicol Sci. 2015, 144(2):238-45. DOI: 10.1093/toxsci/kfu311
10. Chunyang Jiang#, Shun Zhang#, Hongliang Liu, Zhizhong Guan, Qiang Zeng, Cheng Zhang, Rongrong Lei, Tao Xia, Zhenglun Wang, Lu Yang, Yihu Chen, Xue Wu, Xiaofei Zhang, Yushan Cui, Linyu Yu, Aiguo Wang*. Low Glucose Utilization and Neurodegenerative Changes Caused by Sodium Fluoride Exposure in Rat’s Developmental Brain. Neuromol Med. 2014, 16(1): 94-105. DOI: 10.1007/s12017-013-8260-z
