Professor of Occupational and Environmental Health
Director, Division of Environmental Health, Hubei Association of Preventive Medicine
Department of Occupational and Environmental Health
* 976743557@qq.com
Research
Prof. Wu’s major research interests include:
Safety of Drinking Water, both in toxicology of water pollutants and purification of drinking water.
2. Toxicology of Environmental Pollutants, especially in antioxidants and its prevention to environmental pollutants.
3. Pro-oxidation and its application to the chemotherapy of cancer treatment.
Prof. Wu’s research has focused on Toxicology of Environmental Pollutants. He has led two NSFC-funded projects to study antioxidants and its prevention to Environmental pollutants. Prof. Wu’s research has demonstrated that antioxidants can protect against the oxidative stress and cytotoxicity induced by almost all environmental pollutants. These findings may help to find out a method to decrease the damage from current environment pollution.
Prof. Wu is a member of China Drinking Water Specialist and studies both in toxicology of water pollutants and purification of drinking water. He has joined the research of 863 and eleventh 5-years projects of China in safety of drinking water.
Prof. Wu is a member of editorial board of Environment Health, and editor in chief of Guide to Experiments in Environment Health, the textbook of undergraduates in preventive medicine in China.
Education
M.D., 1987, Wuhan University, China
Select Publications
Journal Article
*Corresponding author
1. Chen HJ, Yu RA, He LF, An SJ, Wu ZG, Yang KD, Chen XM.Inhibitory effects of selenium on telomerase activity and hTERT expression in cadmium-transformed 16HBE cells. Biomed Environ Sci. 2007 Aug;20(4):307-12.
2. Shi YQ, Wang YP, Song Y, Li HW, Liu CJ, Wu ZG, Yang KD. p,p'-DDE induces testicular apoptosis in prepubertal rats via the Fas/FasL pathway. Toxicol Lett. 2010 Mar 1;193(1):79-85.
3. Zhou X, Ju Y, Wu Z, Yang K. Disruption of sex hormones and oxidative homeostasis in parturient women and their matching fetuses at an e-waste recycling site in China. International journal of occupational and environmental health. 2013;19(1):22-8
4. Xiang Lun-hui,Wu Feng-hong,Peng Xiao-lin.Xie Hong.Wang Jiachun.Lu Wenqing.Wu* Zhigang.Combined Effects of Microcystins and Extracts of Drinking Water on DNA Damage in HepG2 Cells Environment and Health 2010,1(27):11-14
5. Zhou X, Xiang L, Wu F, Peng X, Xie H, Wang J, Yang K, Lu W, Wu Z. Comparison of extracts and toxicities of organic compounds in drinking water concentrated by single and composite XAD resins. J Water Health. 2013 Dec;11(4):692-9.
6. ZG Wu and J Li. Safety of Drinking Water: Crises and Solutions[B] Changjiang Publisher, 2013.
7. Xuexue Huang, Yuan Xu2, Yanyi Liu, Hong Xie, Jiachun Wang and Zhigang Wu*. Extracellular Ca2+ Selectively Enhances Adriamycin-induced Cell Death in Human Hepatoma Cells. Curr Cancer Drug Targets. 2015;15(6):481-92.
8. Xu Y, Zhou X, Shi C, Wang J, Wu Z*. α-Lipoic acid protects against the oxidative stress and cytotoxicity induced by cadmium in HepG2 cells through regenerating glutathione regulated by glutamate-cysteine ligase. Toxicol Mech Methods. 2015 Oct;25(8):596-603.
9. Shi C, Zhou X, Zhang J, Wang J, Xie H, Wu Z. alpha-Lipoic acid protects against the cytotoxicity and oxidative stress induced by cadmium in HepG2 cells through regeneration of glutathione by glutathione reductase via Nrf2/ARE signaling pathway. Environmental toxicology and pharmacology. 2016;45:274-81.
10. Jiayu Zhang, Xue Zhou, Wenbo Wu, Hong Xie, Jiachun Wang and Zhigang Wu*., Regeneration of glutathione by α-lipoic acid via Nrf2/ARE signaling pathway alleviates cadmium-induced HepG2 cell toxicity. Environmental Toxicology and Pharmacology 2017.51:p.30-37.
11. ZG Wu, H Xie,LL Yao, An active carbon with self-reduced Zinc in situ Patent No. 201010277739.9 2012.
