·Scientific Research
Research Field
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We are interested in novel microbial enzymes invovled in nucleic acids metabolism and the development of enzymatic tools for molecular biotechnology and medicine.
Directions include but not limited to:
Novel single-subunit RNA polymerases--In vitro RNA synthesis;
Novel DNA polymerases--DNA amplification, sequencing and storage;
Novel reverse transcriptase--RNA sequencing and IVD;
Novel nucleases--DNA/RNA processing, modification and genome editing;
Unknown nucleic acids enzymes from bacteriophages and viruses--The dark matter to modern molecular biology, NOTHING IS IMPOSSIBLE!
Paper Publications
MORE+- [1] Lu X.The nuclease-associated short prokaryotic Argonaute system nonspecifically degrades DNA upon activation by target recognition..Nucleic Acids Res..2023:1-12
- [2] Cheng R.Prokaryotic Gabija complex senses and executes nucleotide depletion and DNA cleavage for antiviral defense.Cell Host & Microbe.2023,31(8):1331-1344
- [3] Lu X,Huang F.A Unique m6A-Dependent Restriction Endonuclease from an Archaeal Virus.Microbiology Spectrum.2023
- [4] Xia H,Yu B.Psychrophilic phage VSW-3 RNA polymerase reduces both terminal and full-length dsRNA byproducts in in vitro transcription.RNA biology.2022,19(1):1130-1142
- [5] Ma X,Tan X,Yu B,Sun W.DOCK2 regulates antifungal immunity by regulating RAC GTPase activity..Cellular & Molecular Immunology.2022
Published Books
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