Education

1998 -2003      Ph.D. Pathology, Department of Immunology and Cell Biology, Kyoto University, Japan.

1988 -1991      M.S. Biology, Wuhan University, Wuhan, China.

1989 -1993      B.S. Microbiology, Wuhan University, Wuhan, China

Research Experience

2007-now   Professor, College of Life Science and Technology, HuaZhong University of Science and technology,Wuhan, China.

2005-2007   Research Scientist, Stanford Research Institute, California, USA

2003-2005   Research Scientist, Japan Society for the Promotion of Science (JSPS) and Research Center For Allergy and Immunology, RIKEN, Japan

1991-2004    Lecture, School of Life Science, Wuhan University, China

Research Highlights

Cell signaling and biophysics of cancer matastasis

Ø  Identifying that nuclear SIPA1 interacts with the integrin β1 promoter and activate its transcription; and the phosphorylation of FAK, Akt and MMP9 level were decreased upon SIPA1 knockdown. Moreover, upregulation of SIPA1 via promoter hypomethylation enhances EMT process in breast cancer cells.

Ø  Finding that that high expression of SIPA1 led to a higher relapse rate and worse prognosis among breast cancer patients, and was crucial for breast cancer cells to maintaining the cancer stem cell features. Mechanically, SIPA1 strengthens cancer stemness features by increasing SMADs expression.

Ø  Identifying a novel EDA missense mutation in a Chinese family with NSH, and the site mutations at the interior may be linked to XLHED, while those at the surface are more likely to be associated with NSH by systematic 3D conformation analysis and  RSA calculation (J. Dental Res., 2013). This mutation can impair the interaction with EDAR and downstream NFκB pathway.

Selected Publications

1.         Junyu Cen, Lingyun Feng, Huichuan Ke, Lifeng Bao, Lin Z. Li, Yoshimasa Tanaka, Jun Weng* and Li Su*. Exosomal thrombospondin-1 disrupts the integrity of endothelial intercellular junctions to facilitate breast cancer cell metastasis. Cancers (Basel). 2019，5;11(12)

2.          Li Y, Feng L , Yan W , Hussain I , Su L , Tan B，PVP-templated highly luminescent copper nanoclusters for sensing trinitrophenol and living cell imaging. Nanoscale. 2019，17;11(3):1286-1294.

3.         Xiaoqing Li,†, Ang Lu,†, Wenjie Deng, Li Su, Jing Wang,* and Mingyue Ding * Noninvasive Subcellular Imaging Using Atomic Force Acoustic Microscopy (AFAM) Cells. 2019，5;8(4).

4.         Jing Qiang Huang1,7†, Fa Kai Wei1†, Xiu Li Xu1†, Shi Xing Ye2, Jun Wei Song1, Pei Kun Ding3, Jing Zhu1, He Feng Li1,7, Xin Ping Luo1, Hui Gong4, Li Su5,6, Lin Yang3* and Li Yun Gong1* SOX9 drives the epithelial–mesenchymal transition in non-small-cell lung cancer through the Wnt/β-catenin pathway，J Transl Med，2019，17:143

5.         Zhang YL, Wang RC, Cheng K, Ring BZ, Su L*, Roles of Rap1 signaling in tumor cell migration and invasion. Cancer Biol Med. 2017, 14(1):90-99.

6.         Su W, Zhu P, Wang R, Wu Q, Wang M, Zhang X, Mei L, Tang J, Kumar M, Wang X, Su L*, Dong N. Congenital heart diseases and their association with the variant distribution features on susceptibility genes. Clin Genet. 2016 Jul 18. doi: 10.1111/cge.12835.

7.         Zhang Z, Zhang W, Huang S, Sun Q, Wang Y, Hu Y, Sun N, Zhang Y, Jiang Z, Minato N, Pin JP, Su L*, Liu J. GABAB receptor promotes its own surface expression by recruiting a Rap1-dependent signaling cascade. J Cell Sci. 2015; 128(12):2302-13.

8.         Zhu Q, Zhu P, Zhang Y, Li J, Ma X, Li L, Wang Q, Xue X, Luo L, Li L, Ring HZ, Ring BZ, Su L*. Analysis of Social and Genetic Factors Influencing Heterosexual Transmission of HIV within Serodiscordant Couples in the Henan Cohort. PLoS One. 2015 Jun 11;10(6):e0129979.

9.         Feng AP, Zhang Q, Li M, Jiang XN, Zhang ZY, Zhu P, Wang MW, Wei SZ, Su L*. High SIPA-1 expression in proximal tubules of human kidneys under pathological conditions. J Huazhong Univ Sci Technolog Med Sci. 2015;35(1):64-70. 

10.     Zhang Y, Gong Y, Hu D, Zhu P, Wang N, Zhang Q, Wang M, Aldeewan A, Xia H, Qu X, Ring BZ, Minato N, Su L*. Nuclear SIPA1 activates integrin β1 promoter and promotes invasion of breast cancer cells. Oncogene. 2015；12;34(11):1451-62.   

11.     Ali B. Aldeewan, Zhang Y and Su L*. Bacillus thuringiensis Parasporins Functions on Cancer Cells. Int. J. Pure App. Biosci. 2014, 2 (4): 67-74.

12.     Ali B. Aldeewan, Zhang Y, Meng Y, Peng D, Yu Z, Sun M, Ring BZ and Su L*. A Novel Bacillus thuringiensis Crystal Protein Cry51Aa1with Preferentially Anti-cancer Activity. Journal of Pure and Applied Microbiology, 2014, 8(4): 2637-2644

13.     Yang Y, Luo L, Xu J, Zhu P, Xue W, Wang J, Li W, Wang M, Cheng K, Liu S, Tang Z, Ring BZ, Su L*. Novel EDA p.Ile260Ser mutation linked to non-syndromic hypodontia. Journal of Dental Research, 2013; 92(6):500-506.

14.     Zhu P, Zhu Q, Zhang Y, Ma X, Li Z, Li J, Chen J, Luo L, Ring HZ, Ring BZ, Su L*. ABCB1 variation and treatment response in AIDS patients: initial results of the Henan cohort, PLoS ONE, 2013; 8(1): e55197.

15.     Li X, Hu Z, Qu X, Zhu J, Li L, Ring BZ, Su L*，Putative EPHX1 Enzyme Activity Is Related with Risk of Lung and Upper Aerodigestive Tract Cancers: A ComprehensiveMeta-Analysis. PLoS ONE, 6(3):e14749, 2011