LI YAN

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Professor  
Supervisor of Doctorate Candidates  
Supervisor of Master's Candidates  

Gender:Male

Status:Employed

Department:School of Basic Medical Sciences

Education Level:Postgraduate (Doctoral)

Degree:Doctoral Degree in Philosophy

Discipline:Pathogenic Organisms

Profile

李岩,18luck新利电竞 基础医学院与人畜共患传染病重症诊治全国重点实验室三级教授,博士生导师,病原生物学系党支部书记,同济医院双聘教授,国家高层次青年人才项目,湖北省杰青,湖北省公共卫生青年拔尖人才。目前担任湖北省医学会微生物与免疫学分会副主任委员、教育部病毒学领域教学资源建设项目专家、Wiley旗下VIEW Medicine副主编、Journal of Cellular Biochemistry编委、Military Medical Research青年编委以及The BMJ等二十余个期刊审稿人。于中国科学技术大学获得学士学位,新加坡南洋理工大学获得博士学位,在新加坡科技研究局试验治疗中心从事多年的新药研究工作。

课题组利用生物化学、分子生物学、结构生物学、人工智能、微生物学等多种方法探究包括新冠病毒、利什曼原虫在内等重要病原微生物致病的分子机制,并针对性的开发新型的干预手段。目前课题组申请专利多项,参与的多个新药研发项目已经进入临床试验阶段。以(共同)通讯/第一作者在ScienceLancet MicrobeNucleic Acids ResearchJournal of InfectionNature CommunicationsJournal of Virology等期刊发表SCI论文38篇,H因子26参编高等教育出版社及科学出版社医学微生物学多本教材。获得华为最佳创新合作奖,主持国家自然科学基金新冠专项项目及面上项目、湖北省杰出青年基金、多个公司合作课题、武汉市卫健委应急科研专项、18luck新利电竞 自主创新基金等多个项目,作为骨干成员参与多个国家重点研发计划、湖北省创新研究群体等。

 

代表性文章:

#Co-first author  *Corresponding author

1.    Zhang, H.#, Lv, P.#, Jiang, J., Liu, Y., Yan, R., Shu, S., Hu, B., Xiao, H., Cai, K., Yuan, S.*, & Li, Y.* (2023). Advances in developing of ACE2 derivatives against SARS-CoV-2. The Lancet Microbe, in press.

2.    He, Z., Ke, Z., Wang, W., Liu, Y., Zhang, H.*, & Li, Y.* (2023). Biophysical and biochemical characterization of the binding of the MarR-like transcriptional regulator Saro_0803 to the nov1 promotor and its inhibition by resveratrol. Biomolecules, 13(3), 541.

3.    Zhang, H.#, Hu, B.#, Lv, P.#, Liu, Y.#, Guo, M., Wu, Z., Zhou, K., Dai, M., Yu, X., Liu, Z., Yu, B., Xu, L., Guo, M.*, Cai, K.*, & Li, Y.* (2022). An ACE2-mimicking decoy inhibitor effectively neutralizes SARS-CoV-2 Omicron BA.5 variant. Viruses, 14(11), 2387.

4.    Lv, P.#, Hu, B.#, Hua, R.#, Zhang, J.#, Zhang, H., Liu, Z., Xu, L., He, Z., Li, X., Guo, M., Pan, K., Zhang, Z., Zeng, Q., Wu, Z., Sun, L., Guo, M., Zhou, L., Xu, X., Yu, B., Xu, J., Yuan, S., Guo, M.*, Cai, K.*, Xia, Y.*, & Li, Y.* (2022). A novelly designed protein antagonist confers potent neutralization against SARS-CoV-2 variants of concern. Journal of Infection, 85(3), e72-e76.

5.    Zhao, K.#, Ke, Z.#, Hu, H.#, Liu, Y., Li, A., Hua, R., Guo, F., Xiao, J., Zhang, Y., Duan, L, Yan, X., Gao, Y., Liu, B., Xia, Y.*, & Li, Y.* (2021). Structural basis and function of the N-terminus of SARS-CoV-2 nonstructural protein 1. Microbiology Spectrum, 9(1), e00169-21.

6.    Xu, C.#, Ke, Z.#, Liu, C.#, Wang, Z.#, Liu, D., Zhang, L., Wang, J., He, W., Xu, Z., Li, Y., Yang, Y., Huang, Z., Lv, P., Wang, X., Han, D.*, Li, Y.*, Qiao, N.*, & Liu, B.* (2020). Systemic in silico screening in drug discovery for coronavirus disease (COVID-19) with an online interactive web server. Journal of Chemical Information and Modeling, 60(12), 5735-5745.

7.    Lau, Q.#, Li, J.#, Sani, M.#, Sinha, S.#, Li, Y.#, Ng, F., Kang, C., Bhattacharjya, S., Separovic, F., Verma, C., & Chia, C.* (2018). Elucidating the bactericidal mechanism of action of the linear antimicrobial tetrapeptide BRBR-NH2. Biochimica et Biophysica Acta (BBA) - Biomembranes, 1860(8), 1517-1527.

8.    Li, Y.#, Zhang, Z.#, Phoo, W.#, Loh, Y., Li, R., Yang, H., Jansson, A., Hill, J., Keller, T., Nacro, K.*, Luo, D.*, & Kang, C.* (2018). Structural insight into the inhibition of Zika virus NS2B-NS3 protease by a small-molecule inhibitor. Structure, 26(4), 555-564.e3.

9.    Li, Y., Lee, M., Loh, Y., & Kang, C.* (2018). Secondary structure and membrane topology of Dengue Virus NS4A protein in micelles. Biochimica et Biophysica Acta (BBA) - Biomembranes, 1860(2), 442-450.

10. Li, Y.#, Zhang, Z.#, Phoo, W., Loh, Y., Wang, W., Liu, S., Chen, M., Hung, A., Keller, T., Luo, D.*, & Kang, C.* (2017). Structural dynamics of Zika virus NS2B-NS3 protease binding to dipeptide inhibitors. Structure, 25(8), 1242-1250.e3.

11. Zhang, Z.#, Li, Y.#, Loh, Y., Phoo, W., Hung, A., Kang, C.*, & Luo, D.* (2016). Crystal structures of unlinked NS2B-NS3 protease from Zika Virus. Science, 354(6319), 1597-1600.

12. Phoo, W.#, Li, Y.#, Zhang, Z., Lee, M., Loh, Y., Tan, Y., Ng, E., Lescar, J., Kang, C.*, & Luo, D.* (2016). Structure of the NS2B-NS3 protease from Zika virus after self-cleavage. Nature Communications, 7, 13410.

13. Li, Y., Wong, Y., Lee, M., Li, Q., Wang, Q., Lescar, J., Shi, P., & Kang, C.* (2016). Secondary structure and membrane topology of the full-length Dengue Virus NS4B in micelles. Angewandte Chemie International Edition, 55(39), 12068-12072.

14. Li, Y., Wong, Y., Ng, F., Liu, B., Wong, Y., Poh, Z., Liu, S., Then, S., Lee, M., Ng, H., Huang, Q., Hung, A., Cherian, J., Hill, J., Keller, T., & Kang, C.* (2016). Escherichia coli topoisomerase IV E subunit and an inhibitor binding mode revealed by NMR spectroscopy. Journal of Biological Chemistry, 291(34), 17743-17753.

15. Li, Y.#, Li, Q.#, Wong, Y., Liew, L., & Kang, C.* (2015). Membrane topology of NS2B of dengue virus revealed by NMR spectroscopy. Biochimica et Biophysica Acta (BBA) - Biomembranes, 1848(10 Pt A), 2244-2252.

16. Li, Y.#, To, J.#, Verdia-Baguena, C.#, Dossena, S., Surya, W., Huang, M., Paulmichl, M., Liu, D., Aguilella, V., & Torres, J.* (2014). Inhibition of the human respiratory syncytial virus small hydrophobic protein and structural variations in a bicelle environment. Journal of Virology, 88(20), 11899-11914.

17. Li, Y.#, Surya, W.#, Claudine, S., & Torres, J.* (2014). Structure of a conserved Golgi complex-targeting signal in coronavirus envelope proteins. Journal of Biological Chemistry, 289(18), 12535-12549.

18. Wong, L.#, Li, Y.#, Pillay, S., Frolova, L., & Pervushin, K.* (2012). Selectivity of stop codon recognition in translation termination is modulated by multiple conformations of GTS loop in eRF1. Nucleic Acids Research, 40(12), 5751-5765.



Educational Experience

2003.9 2007.6

  • 中国科学技术大学
  • Bachelor's degree
  • Undergraduate (Bachelor’s degree)

2008.1 2018.10

  • 新加坡南洋理工大学
  • Doctoral Degree
  • Postgraduate (Doctoral)

Work ExperienceMore>>

2018.5 Now
  • 18luck新利电竞
  • 同济医学院基础医学院病原生物学系
  • 教授,博士生导师,硕士生导师
2014.11 2018.5
  • 新加坡科技研究局
  • 试验治疗中心
  • 研究员
2014.10 2014.10
  • 日本理化学研究所
  • 生命科学技术中心
  • 访问学者

Social AffiliationsMore>>

2023.5 Now

  • VIEW Medicine副主编

2023.7 Now

  • 湖北省医学会微生物与免疫学分会副主任委员

2019.1 Now

  • 常委,湖北医学生物免疫学会转化医学专委会