·Paper Publications
- [1] Hu W, Wang Z, Zhang H, Mahaman YAR, Huang F, Meng D, Zhou Y, Wang S, Jiang N, Xiong J, Westermarck J, Lu Y, Wang J, Wang X, Shentu Y, Liu R. Chk1 Inhibition Ameliorates Alzheimer's Disease Pathogenesis and Cognitive Dysfunction Through CIP2A/PP2A Signaling. Neurotherapeutics. 2022 Mar;19(2):570-591. doi: 10.1007/s13311-022-01204-z..
- [2] Meng D, Yang M, Hu L, Liu T, Zhang H, Sun X, Wang X, Chen Y*, Jin Y*, Liu R*. Rifaximin protects against circadian rhythm disruption-induced cognitive impairment through preventing gut barrier damage and neuroinflammation. J Neurochem. 2022 Oct 3. doi: 10.1111/jnc.15701..
- [3] Hu WT, Liuyang ZY, Tian Y, Liang JW, Zhang XL, Zhang HL, Wang G, Huo Y, Shentu YP, Wang JZ, Wang XC, Lu YM, Westermarck J, Man HY*, Liu R*. CIP2A deficiency promotes depression-like behaviors in mice through inhibition of dendritic arborization. EMBO Rep. 2022 Oct 28:e54911. doi:10.15252/embr.202254911..
- [4] Zhang H, Yang M, Wang X, Wei H, Du M, Wang M, Wang J, Chen Z, Peng C*, Liu R*. Zinc induces reactive astrogliosis through ERK dependent activation of Stat3 and promotes synaptic degeneration. J Neurochem. 2021 Dec;159(6):1016-1027..
- [5] Wei H, Zhang HL, Wang XC, Xie JZ, An DD, Wan L, Wang JZ, Zeng Y, Shu XJ, Westermarck J, Lu YM, Ohlmeyer M*, Liu R*. Direct Activation of Protein Phosphatase 2A (PP2A) by Tricyclic Sulfonamides Ameliorates Alzheimer's Disease Pathogenesis in Cell and Animal Models. Neurotherapeutics. 2020 Feb 24. doi: 10.1007/s13311-020-00841-6..
- [6] Zhou Y, Yang D, Chen H, Zheng C, Jiang H, Liu X, Huang X, Ye S, Song S, Jiang N, Zhao Z, Ma S, Ma J, Huang K, Chen C, Fan X, Gong Y, Wang X, Fan J, Liu R*, Shentu Y*. Polyphyllin I attenuates cognitive impairments and reduces AD-like pathology through CIP2A-PP2A signaling pathway in 3XTg-AD mice. FASEB J. 2020;34(12):16414-16431.
- [7] Zhou Y, Liu X, Ma S, Zhang N, Yang D, Wang L, Ye S, Zhang Q, Ruan J, Ma J, Wang S, Jiang N, Zhao Z, Zhao S, Zheng C, Fan X, Gong Y, Abdoul Razak MY, Hu W, Pan J, Wang X, Fan J, Li J, Liu R*, Shentu Y*. ChK1 activation induces reactive astrogliosis through CIP2A/PP2A/STAT3 pathway in Alzheimer's disease. FASEB J. 2022 Mar;36(3):e22209..
- [8] Shentu YP, Huo Y, Feng XL, Gilbert J, Zhang Q, Liuyang ZY, Wang XL, Wang G, Zhou H, Wang XC, Wang JZ, Lu YM, Westermarck J, Man HY*, Liu R*. CIP2A Causes Tau/APP Phosphorylation, Synaptopathy, and Memory Deficits in Alzheimer's Disease. Cell Rep. 2018 Jul 17;24(3):713-723. doi: 10.1016/j.celrep.2018.06.009..
- [9] Shentu YP*, Hu WT, Liang JW, Liuyang ZY, Wei H, Qun W, Wang XC, Wang JZ, Westermarck J, Liu R*. Genistein Decreases APP/tau Phosphorylation and Ameliorates Aβ Overproduction Through Inhibiting CIP2A. Curr Alzheimer Res. 2019;16(8):732-740..
- [10] O'Connor M, Shentu YP, Wang G, Hu WT, Xu ZD, Wang XC, Liu R*, Man HY*. Acetylation of AMPA Receptors Regulates Receptor Trafficking and Rescues Memory Deficits in Alzheimer's Disease. iScience. 2020 Aug 15;23(9):101465. doi: 10.1016/j.isci.2020.101465. .