本人长期从事细胞力学，生物力医学，干细胞力学生物学以及肿瘤力学生物学相关研究，在 Science Advances, Nature Communications, Nature Materials, Nature Protocols 和 Cell Research 等杂志发表SCI论文 18 篇，引用>1200次。已申请并持有 6项抗癌药物研发专利。

本课题组主要从事力学信号调控肿瘤及胚胎干细胞命运的相关研究，主要包括：

1.用单细胞加力装置探究力学信号快速入核并选择性激活基因表达的机制；

2.模拟体内力学微环境，诱导胚胎干细胞胚层有序分化，进行再生医学研究；

3.调节肿瘤力学微环境，控制肿瘤干细胞的分化及转移。

4.基于生物力医学理念，筛选并优化抗肿瘤药物，寻找新的抗癌靶点。

5.研究肿瘤干细胞逃逸免疫细胞杀伤的机制，探究新的肿瘤免疫治疗策略。

欢迎对以上课题感兴趣的同学来信咨询，我们课题组长期招收博士后，研究助理，博士研究生，硕士研究生。

代表性论文：

      1.  Mohagheghian E#, Luo J#, Yavitt FM#, Wei F#, Bhala P, Amar K, Rashid F, Wang Y, Liu X, Ji C,Chen J, Arnold DP, Liu Z, Anseth KS*, Wang N*. Quantifying stiffness and forces of tumor colonies and embryos using a magnetic microrobot. Science Robotics. 2023 Jan 25;8(74):eadc9800. 

      2. Zhang, Y., Dong, Q., An, Q., Zhang, C., Mohagheghian, E., Niu, B., Qi, F., Wei, F., Chen, S., Chen, X., Wang, A., Cao, X*., Wang, N*., & Chen, J*. (2022). Synthetic Retinoid Kills Drug-Resistant Cancer Stem Cells via Inducing RARγ-Translocation-Mediated Tension Reduction and Chromatin Decondensation. Advanced Science (Weinh). 2022 Nov;9(31):e2203173. 

     3.Amar K#, Wei F#, Chen J#, Wang N*. Effects of forces on chromatin. APL Bioengineering. 2021 Oct 13;5(4):041503.

     4.  Qi, F.#, Qin, W.#, Zhang, Y.#, Luo, Y., Niu, B., An, Q., Yang, B., Shi, K., Yu, Z., Chen, J*., Cao, X.*, & Xia, J*. (2021). Sulfarotene, a synthetic retinoid, overcomes stemness and sorafenib resistance of hepatocellular carcinoma via suppressing SOS2-RAS pathway. J Exp Clin Cancer Res. 2021 Sep 4;40(1):280. 

     5. Sun, J#., Chen, J#., Amar, K., Wu, Y., Jiang, M., & Wang, N*. (2021). LAP2β transmits force to upregulate genes via chromatin domain stretching but not compression. Acta Biomaterialia. 2021 Oct 23:S1742-7061(21)00700-5.

6.      Sun J^$, Chen JW^$, Mohagheghian E, Wang N^*.  Force induced gene upregulation does not follow the weak power law but depends on H3K9 demethylation. Science advances，6, 14, eaay9095,2020.  ^$Co-first authors. ^*Corresponding senior author.

7.      Chen JW^$, Cao X^$, An Q, Zhang Y, Li K, Yao W, Shi F, Pan Y, Jia Q, Zhou W, Yang F, Wei F, Wang N^*, Yu B^*. Inhibition of cancer stem cell like cells by a synthetic retinoid. Nature Communications Apr 11; 9 (1):1406, 2018.  ^$Co-first authors.  ^*Co-Corresponding author

8.      Tan Y^$, Tajik A^$, Chen JW^$, Jia Q, Chowdhury F, Wang L, Junjian Chen JJ, Zhang S, Ying Hong Y, Yi H, Wu DC, Zhang Y, Wei F, Poh YC, Seong J, Singh R, Lin LJ, Doğanay S, Li Y, Jia H, Ha T, Wang Y, Huang B, Wang N^*. Matrix softness regulates plasticity of tumour-repopulating cells via H3K9 demethylation and Sox2 expression. Nature Communications. 5: 4619, 2014. ^$Co-first authors.^*Corresponding senior author.

9.      J Chen, N Wang. Tissue cell differentiation and multicellular evolution via cytoskeletal stiffening in mechanically stressed microenvironments. Acta Mechanica Sinica, 2018

10.      Mohagheghian E, Luo J, Chen JW, Chaudhary G, Chen J, Sun J, Ewoldt RH, Wang N^*. Quantifying compressive forces between living cell layers and within tissues using elastic round microgels. Nature Communications. May 14; 9(1):1878, 2018.

11.      Zhang Y, Wei F, Poh YC, Jia Q, Chen J, Chen J, Luo J, Yao W, Zhou W, Huang W, Yang F, Zhang Y, Wang N. Interfacing 3D magnetic twisting cytometry with confocal fluorescence microscopy to image force responses in living cells. Nature Protocols 12, 1437–1450, 2017.

12.      Ma J, Zhang Y, Tang K, Zhang H, Yin X, Li Y, Xu P, Sun Y, Ma R, Ji T, Chen JW, Zhang S, Zhang T, Luo S, Jin Y, Luo X, Li C, Gong H, Long Z, Lu J, Hu Z, Cao X, Wang N, Yang X, Huang B. Reversing drug resistance of soft tumor-repopulating cells by tumor cell-derived chemotherapeutic microparticles. Cell Research 26(6):713-27, 2016.

13.      Poh YC, Chen JW, Ying Hong Y, Yi H, Zhang S, Chen JJ, Wu DC, Wang L, Jia Q, Singh R, Yao W, Tan Y, , Tajik A, Tanaka TS, Wang N^*.Generation of organized germ layers from a single mouse embryonic stem cell. Nature Communications. May 30; 5:4000, 2014.^*Corresponding senior author. doi: 10.1038/ncomms5000.

14.     Liu J^$, Tan Y^$, Zhang H, Zhang Y, Xu P, Chen JW, Poh YC, Tang K, Wang N^*, Huang B^*. Soft fibrin gels promote selection and growth of tumorigenic cells.  Nature Materials. Published online July 1, 11(8):734-41, 2012. ^$Co-first authors.  ^*Co-corresponding senior authors.