骆海明，教授，博士生导师。入选国家高层次人才计划、湖北省百人计划。2013年获得18luck新利电竞 生物医学工程专业博士学位（湖北省优秀博士学位论文）。2013-2015年美国威斯康辛大学麦迪逊分校博士后；2015-2018年美国哈佛医学院麻省总医院博士后；2016-2018年美国麻省理工大学麦戈文脑研究所研究助理。在Science Advances, PNAS、Clinical Cancer Research、Journal of Nuclear Medicine、Biosensors & Bioelectronics、Theranostics、Journal of Nanobiotechnology等期刊上发表SCI论文20多篇。获得授权美国发明专利1项、欧洲发明专利1项，中国发明专利7项，申请中国发明专利多项。
目前研究方向：
1、老年痴呆症的发病机制探究、血液生物标志物的发掘、防治策略开发和体外诊断检测应用
具体涉及：基于单细胞测序与生物信息学进行阿尔兹海默病早期标志物的发掘及相关诊断检测方法的开发；阿尔兹海默病的发病机理研究；阿尔兹海默病与肠道微生物关系研究及相关防治策略的开发；基于深度学习进行AD相关中药的筛选与开发；
2、肿瘤分子成像与诊断检测
阿尔兹海默病方向代表性论文（*为通讯作者）
1. Hu Shun, Zhang Liding, Su Ying, Liang Xiaohan, Yang Jie, Luo Qingming, Luo Haiming*. Sensitive detection of multiple blood biomarkers via immunomagnetic exosomal PCR for the diagnosis of Alzheimer’s disease. Science Advances. 2024, in press.
2. Zhang Liding, Su Ying, Liang Xiaohan, Cao Kai, Luo Qingming, Luo Haiming*. Ultrasensitive and point-of-care detection of plasma phosphorylated tau in Alzheimer's disease using colorimetric and surface-enhanced Raman scattering dual-readout lateral flow assays. Nano Research. 2023;16(5):7459-7469
3. Zhang Liding, Cao Kai, Su Ying, Hu Shun, Liang Xiaohan, Luo Qingming, Luo Haiming*. Colorimetric and surface-enhanced Raman scattering dual-mode magnetic immunosensor for ultrasensitive detection of blood phosphorylated tau in Alzheimer's disease. Biosensor and Bioelectronics, 2023;222:114935.
4. Liu Ni , Liang Xiaohan, Yang Changwen, Hu Shun, Luo Qingming, Luo Haiming*. Dual-targeted magnetic mesoporous silica nanoparticles reduce brain amyloid-β burden via depolymerization and intestinal metabolism. Theranostics. 2022, 12: 6646-6664
5. Hu Shun, Yang Changwen, Li Yanqing, Luo Qingming, Luo Haiming*. Nanozyme sensor array based on manganese dioxide for the distinction between multiple amyloid β peptides and their dynamic aggregation process. Biosensor and Bioelectronics. 2022,199:113881
6. Liu Ni, Yang Changwen, Liang Xiaohan, Cao Kai, Xie Jun, Luo Qingming, Luo Haiming*. Mesoporous silica nanoparticle-encapsulated Bifidobacterium attenuates brain Aβ burden and improves olfactory dysfunction of APP/PS1 mice by nasal delivery. Journal of Nanobiotechnology. 2022, 20:439
7. Hu Shun, Yang Changwen, Luo Haiming*. Current trends in blood biomarker detection and imaging for Alzheimer's disease. Biosensor and Bioelectronics. 2022, 210:114278
8. Zhang Liding, Du Xuewei, Su Ying, Niu Shiqi, Li Yanqing, Liang Xiaohan, Luo Haiming*. Quantitative assessment of AD markers using naked eyes: point-of-care testing with paper-based lateral flow immunoassay. Journal of Nanobiotechnology. 2021, 19(1):366
9. Zhang Liding, Yang Changwen, Li Yanqing, Niu Shiqi, Liang Xiaohan, Zhang Zhihong, Luo Qingming, Luo Haiming*. Dynamic changes in the levels of amyloid-β42 species in the brain and periphery of APP/PS1 mice and their significance for Alzheimer's disease. Frontiers in Molecular Neuroscience. 2021, 14:723317
10. Liang Xiaohan, Luo Haiming*. Optical Tissue Clearing: Illuminating Brain Function and Dysfunction. Theranostics. 2021,11(7):3035-3051
肿瘤分子成像与诊断检测方向代表性文章
1. Luo Haiming*, Yang Changwen, Kuang Dong, Chan W. Annie*. Visualizing dynamic changes in PD-L1 expression in non-small-cell lung carcinoma with radiolabeled recombinant human PD1. European Journal of Nuclear Medicine and Molecular Imaging. 2022, 49(8):2735-2745 (IF 10.057)
2. Luo Haiming*, Lu Lisen, Liu Ni, Li Qingqing, Yang Xiaoquan, Zhang Zhihong*. Curcumin loaded sub-30 nm targeting therapeutic lipid nanoparticles for synergistically blocking nasopharyngeal cancer growth and metastasis. Journal of Nanobiotechnology. 2021, 19(1):224. (IF 9.464)
3. Luo Haiming, England G Christopher, Goel Shreya, Graves A Stephen, Ai Fanrong, Liu Bai, Theuer P Charles, Wong C Hing, Nickles J Robert, Cai Weibo. ImmunoPET and Near-Infrared Fluorescence Imaging of Pancreatic Cancer with a Dual-Labeled Bispecific Antibody Fragment. Molecular Pharmaceutics, 2017, 14(5):1646-1655.
4. Luo Haiming, Christopher G England, Shi Sixiang, Graves A Stephen, Hernandez Reinier, Liu Bai, Theuer P Charles, Wong C Hing, Nickles J Robert, Cai Weibo. Dual Targeting of Tissue Factor and CD105 for Preclinical PET Imaging of Pancreatic Cancer. Clinical Cancer Research, 2016, 22(15):3821-30.
5. Luo Haiming#, Christopher G England#, Graves A Stephen, Sun Haiyan, Liu Glenn, Nickles J Robert, Cai Weibo. PET of VEGFR2 in cancer with 64Cu-labeled ramucirumab. Journal of Nuclear Medicine, 2016, 57(2):285-90.
6. Luo Haiming#, Hernandez Reinier#, Hong Hao, Graves A Stephen, Yang Yunan, Christopher G England, Theuer P Charles, Nickles J Robert, Cai Weibo. Noninvasive brain cancer imaging with a bispecific antibody fragment, generated via click chemistry. Proceedings of the National Academy of Sciences, 2015, 112(41):12806-11.
7. Luo Haiming, Hong Hao, Slater R Michael, Graves A Stephen, Shi Sixiang, Yang Yunan, Nickles J Robert, Fan Frank, Cai Weibo. PET of c-Met in cancer with 64Cu-labeled Hepatocyte Growth Factor. Journal of Nuclear Medicine, 2015, 56(5):758-63.
8. Luo Haiming, Lu Lisen, Yang Fei, Wang Liang, Yang Xiaoquan, Luo Qingming, Zhang Zhihong. Nasopharyngeal Cancer-Specific Therapy Based on Fusion Peptide-Functionalized Lipid Nanoparticles. ACS Nano, 2014, 8(5):4334-47.
9. Luo Haiming#, Shi Jiyun#, Jin Honglin, Fan Di, Lu Lisen, Wang Fan, Zhang Zhihong. An (125)I-labeled octavalent peptide fluorescent nanoprobe for tumor-homing imaging in vivo. Biomaterials, 2012, 33(19):4842-50.
10. Luo Haiming, Yang Jie, Jin Honglin, Huang Chuan, Fu Jianwei, Yang Fei, Gong Hui, Zeng Shaoqun, Luo Qingming, Zhang Zhihong. Tetrameric Far-Red Fluorescent Protein as a Scaffold to Assemble an Octavalent Peptide Nanoprobe for Enhanced Tumor Targeting and Intracellular Uptake In Vivo. The FASEB Journal, 2011, 25(6):1865-1873.
专利
1、骆海明、张立定。用于检测人淀粉样蛋白-β双抗夹心ELISA检测试剂盒。专利号：ZL202011227418.8
2、骆海明、骆清铭、张立定。用于检测人淀粉样蛋白-β的胶体金免疫层析试纸及其制备。专利号：ZL202110067679.6
3、骆海明、刘妮、胡顺、曹凯。一种用于清除β-淀粉样蛋白的特异性捕获载体及其应用。专利号：ZL202110345476.9
4、骆海明、张立定。分泌抗丝氨酸磷酸化tau蛋白单克隆抗体的杂交瘤细胞株。专利号：ZL202110067436.2
5、骆海明、刘妮、胡顺、曹凯、杨昌文。纳米材料用于制备鼻腔纳米制剂脑靶向递送肠道药物应用。专利号：ZL202110718344.6
